Cloned (Comment) | Organism |
---|---|
isozyme UGT2B15, sequence comparisons, realtime PCR expression analysis | Homo sapiens |
isozyme UGT2B17, sequence comparisons, realtime PCR expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | suppression of isozyme UGT2B15 by RNAsi leading to 70% reduction of the UGT mRNA levels and over 75% reduction of glucuronidation of androgens in prostate cancer LNCaP cells | Homo sapiens |
additional information | suppression of isozyme UGT2B17 by RNAsi leading to 70% reduction of the UGT mRNA levels and over 75% reduction of glucuronidation of androgens in prostate cancer LNCaP cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | ? | - |
? | |
additional information | Homo sapiens | isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | Homo sapiens | in epithelial cells of the human prostate | UDP + ? | - |
? | |
UDP-D-glucuronate + androsterone | Homo sapiens | in epithelial cells of the human prostate | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dihydrotestosterone | Homo sapiens | in epithelial cells of the human prostate | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75795 | isozyme UGT2B17; isozyme UGT2B17 | - |
Homo sapiens | P54855 | isozyme UGT2B15; isozyme UGT2B15 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | Homo sapiens | ? | - |
? | |
additional information | isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | Homo sapiens | ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | in epithelial cells of the human prostate | Homo sapiens | UDP + ? | - |
? | |
UDP-D-glucuronate + androsterone | - |
Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + androsterone | in epithelial cells of the human prostate | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dihydrotestosterone | - |
Homo sapiens | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + dihydrotestosterone | in epithelial cells of the human prostate | Homo sapiens | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 2B15 | - |
Homo sapiens |
UDP-glucuronosyltransferase 2B17 | - |
Homo sapiens |
UGT2B15 | - |
Homo sapiens |
UGT2B17 | - |
Homo sapiens |
uridine diphosphate-glucuronosyltransferase 2 B15 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |